Based on our projections, the best bet against the spread in the NFL among Week 12’s 13 matchups is Steelers -3.5 — for more suggestions, including parlay possibilities, see below.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 12 Spread Bets

Jump to Matchup:

ARI-SEA | SF-GB | PHI-LAR | BAL-LAC | PIT-CLE

Pick: Cardinals -1 vs. Seahawks

• Matchup: Arizona Cardinals at Seattle Seahawks
• Projected Winner & Margin: Cardinals by 3.1 points (Bet on this game at BetMGM)
• Spread: Cardinals -1
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -2.5 vs. 49ers

• Matchup: San Francisco 49ers at Green Bay Packers
• Projected Winner & Margin: Packers by 9.3 points (Bet on this game at BetMGM)
• Spread: Packers -2.5
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Eagles -3 vs. Rams

• Matchup: Philadelphia Eagles at Los Angeles Rams
• Projected Winner & Margin: Eagles by 3.5 points (Bet on this game at BetMGM)
• Spread: Eagles -3
• Time: 8:20 p.m. ET
• Date: Nov. 24
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers +3 vs. Ravens

• Matchup: Baltimore Ravens at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 2.3 points (Bet on this game at BetMGM)
• Spread: Ravens -3
• Time: 8:15 p.m. ET
• Date: Nov. 25
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -3.5 vs. Browns

• Matchup: Pittsburgh Steelers at Cleveland Browns
• Projected Winner & Margin: Steelers by 16.4 points (Bet on this game at BetMGM)
• Spread: Steelers -3.5
• Time: 8:15 p.m. ET
• Date: Nov. 21
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 12 Total Bets

Jump to Matchup:

Under 50.5 – Lions vs. Colts

• Matchup: Detroit Lions at Indianapolis Colts
• Projected Total: 47.7 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 50.5 – Ravens vs. Chargers

• Matchup: Baltimore Ravens at Los Angeles Chargers
• Projected Total: 45.8 points (Bet on this game at BetMGM)
• Time: 8:15 p.m. ET
• Date: Nov. 25
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 47.5 – 49ers vs. Packers

• Matchup: San Francisco 49ers at Green Bay Packers
• Projected Total: 46.8 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 48.5 – Eagles vs. Rams

• Matchup: Philadelphia Eagles at Los Angeles Rams
• Projected Total: 44.5 points (Bet on this game at BetMGM)
• Time: 8:20 p.m. ET
• Date: Nov. 24
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 47.5 – Cardinals vs. Seahawks

• Matchup: Arizona Cardinals at Seattle Seahawks
• Projected Total: 46.3 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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