Only a single top-25 game is on Wednesday’s college basketball schedule. That matchup is the UConn Huskies taking on the DePaul Blue Demons at Wintrust Arena. For ATS picks for each game, see the article below.

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AP Top 25 Picks ATS Today

DePaul Blue Demons vs. No. 11 UConn Huskies

Spread Prediction

• Computer Prediction: UConn 76, DePaul 74
• Projected Favorite: UConn by 2.2 points
• Pick ATS: DePaul (+10.5)

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Key Facts

• Time: 2:00 PM ET
• Location: Chicago, Illinois
• Venue: Wintrust Arena
• TV Channel: CBS Sports Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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